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Archive for the ‘ research-biomedical/clinical’ Category

Advances in brain science

Thursday, September 25th, 2014

Robert J Corona Jr, DO,MBA,FCAP,FASCPNeuropathologist Robert Corona, DO, helps us understand a new study from the National Institutes for Health (NIH), and what the new three-dimensional tissue model could mean for scientists studying the human brain. Corona is professor and chair of the Pathology, and vice president for Innovation and Business Development at Upstate Medical University. Read the story: Bioengineers create functional 3D brain-like tissue


Exploring how to better protect bone from radiation therapy during cancer treatment

Thursday, September 18th, 2014

megan oest phd

Targeted radiation therapy can be effective in reducing the size of a tumor, but it can leave bones more susceptible to fractures in the years after cancer.

Studying stem cells for possible solutions are Megan Oest, PhD, assistant professor of orthopedic surgery, and Timothy Damron, MD, professor of orthopedic surgery, cell and developmental biology and neuroscience and physiology. Stem cells have the ability to develop into many different cell types, depending on the body’s needs.

Of the bone cells that are alive at the time of radiation, Oest and Damron have noticed that some die and are never replenished. They are experimenting with chemical or biological methods to prevent damage to these particular cells. Perhaps in the future, patients could receive an injection of a protective substance before undergoing radiotherapy.

 It’s also possible, Oest theorizes, that patients could undergo something like a stem cell transplant after their therapy. Healthy cells could come from a donor, or from elsewhere in the patient’s body. She and Damron have learned that when radiation is applied to one leg, cells from the opposite leg remain undamaged. “In theory, if it worked, you could actually take cells from the healthy side of the patient and put them into the unhealthy side,” she says.

Oest and Damron are among dozens of researchers who have received grants from the Carol M. Baldwin Breast Cancer Research Fund of CNYsince 2002.


‘Expert Advice’: How to move a new medical idea forward

Thursday, September 18th, 2014

Robert J Corona Jr, DO,MBARobert Corona, DO, explains how the new Upstate MIND center will help transform innovative ideas in the medical field into useful, tangible ways to improve the human condition and the delivery of health care. In addition to leading the center, Corona is professor and chair of pathology at Upstate Medical University.


Breast cancer research asks: what is the best way to restrict estrogen?

Thursday, September 11th, 2014

Debashis Ghosh, MSc, PhD

Estrogen is crucial to human life for men and women, but once a woman enters menopause, excess estrogen can lead to breast cancer. Up to 80 percent of the breast cancers detected in women after menopause are triggered and proliferated by estrogen, explains Debashis Ghosh, PhD. 

Ghosh, a professor of pharmacology, collaborates with Juntao Luo, PhD, assistant professor of pharmacology, about ways to deliver new inhibitors of aromatase, the molecule that makes estrogen, to the tumor sites in animal breast cancer models.  Having elucidated the molecular mechanism of how aromatase works, the Ghosh group has designed novel aromatase inhibitors, which are being tested in his lab.        

“Some of our compounds have performed better, much better in breast cancer cells than the current drug, which is known as Aromasin or exemestane,” says Ghosh. The next step would be testing the compounds in laboratory animals. 

Ghosh is one of dozens of Upstate researchers who have received grants from the Carol M. Baldwin Breast Cancer Research Fund of CNY since 2002.

 


Understanding attention deficit hyperactivity disorder (ADHD)

Wednesday, August 13th, 2014

Researcher and psychiatrist Stephen V Faraone, PhDStephen Faraone, PhD, helps us understand Attention Deficit Hyperactivity Disorder (ADHD), one of the most common childhood disorders that can continue through adolescence and adulthood. Faraone is an international expert in ADHD research, and distinguished professor of Psychiatry and of Neuroscience & Physiology at Upstate Medical University.

 


Biosensors for detecting neural diseases

Wednesday, July 30th, 2014

Sharon A Brangman, MDAlex Travis PhDGeriatrician Sharon Brangman, MD, is joined by researcher Alexander Travis, PhD, to talk about their collaborative work on a new research project that hopes to improve the diagnosis of neural diseases and neurotoxins, including stroke, Alzheimer’s Disease, and traumatic brain injury.  In addition to Upstate, the following campuses are participating in the project: University at Buffalo, College of Nanoscale Science and Engineering, Cornell University and SUNY Cortland. Brangman is professor of Medicine and division chief of Geriatrics at Upstate, and director of the Alzheimer’s Disease Assistance Center (ADAC). Travis is associate professor of Reproductive Biology at the Baker Institute for Animal Health at Cornell University. 


Creating a partnership for research on issues related to aging

Wednesday, July 30th, 2014

Sharon Brangman, MD

Upstate geriatrician Sharon Brangman, MD, serves as the principal investigator for a new project that will establish the State of New York (SUNY) Network Aging Partnership (SNAP) to coordinate collaborative research across SUNY’s four medical universities to facilitate competition for scientific funding, accelerate publication of research projects, and recruit and mentor trainees. The partnership will investigate frailty, and ways to enhance lifespan across the health spectrum. In addition to Upstate, project participants include the University at Buffalo, Downstate Medical Center and Stony Brook University. Read the story: Upstate Medical University among nine SUNY campuses to share $900,000 funding


Upstate researcher wins $50K state grant to develop medical device

Wednesday, June 25th, 2014

Gary NiemanUpstate researcher Gary Nieman, MS, has been awarded a $50,000 grant from the SUNY Technology Accelerator Fund (TAF) to develop a Minimally-invasive Infusion and Suction Therapy (MIST), a novel medical device that removes harmful abdominal fluid buildup caused by trauma, sepsis, or burns. Nieman is associate professor of surgery, senior research scientist, and director of the Cardiopulmonary and Critical Care Lab at Upstate Medical University. 


What Upstate’s new cord blood center means to Central New York

Thursday, May 22nd, 2014

Nicholas Greco, PhDNicholas Greco, PhD, executive director and Tissue Bank director for the Upstate Cord Blood Bank, describes the process of building a new cord blood center, which is currently under construction at Upstate’s Community campus. Greco talks about what the new center will bring to the community, the current uses of cord blood in treatments and cures approved by the FDA, and what is on the horizon for its use in regenerative medicine.  Read the story: Nicholas Greco, PhD, to lead the Upstate Cord Blood Bank
Listen to an interview with Dr. Robert Silverman: Upstate breaks ground for umbilical cord blood bank


Study shows diabetes related complications are improving

Wednesday, May 21st, 2014

Ruth S Weinstock, MD, PhDRuth Weinstock, MD, PhD, medical director of the Joslin Diabetes Center at Upstate, shares an encouraging report from federal researchers that indicates efforts at reducing the complications related to diabetes are paying off.  Read the study: Changes in Diabetes-Related Complications in the United States, 1990–2010  Read the article: For Diabetics, Health Risks Fall Sharply
Call 315-464-9007 for information about getting involved in research, both type 1 and type 2 diabetes…..children or adults.


How close are we to a cure for HIV?

Wednesday, May 21st, 2014

Bernard J Poiesz, MDUpstate professor of medicine and researcher Bernard Poiesz, MD, shares his perspective on how close we are to a cure for the human immunodeficiency virus (HIV), the virus that causes AIDS. Poiesz is the division chief of Hematology and Oncology, Oncology, and the Regional Oncology Center at Upstate Medical University.
Read the story: Early Treatment Is Found to Clear H.I.V. in a 2nd Baby.

 


Update on new cystic fibrosis drug

Wednesday, April 30th, 2014

Ran D Anbar, MDUpstate pulmonologist Ran Anbar, MD, gives us an update on the promising new drug Kalydeco™ that treats the underlying cause of cystic fibrosis, and an ongoing clinical trial at Upstate. Anbar is the director of the pediatric pulmonary and cystic fibrosis center at Upstate Golisano Children’s Hospital, and author of a new book about the impact of psychological factors in the treatment of disease titled “Functional Symptoms in Pediatric Disease: A Clinical Guide.”