Targeted radiation therapy can be effective in reducing the size of a tumor, but it can leave bones more susceptible to fractures in the years after cancer.
Studying stem cells for possible solutions are Megan Oest, PhD, assistant professor of orthopedic surgery, and Timothy Damron, MD, professor of orthopedic surgery, cell and developmental biology and neuroscience and physiology. Stem cells have the ability to develop into many different cell types, depending on the body’s needs.
Of the bone cells that are alive at the time of radiation, Oest and Damron have noticed that some die and are never replenished. They are experimenting with chemical or biological methods to prevent damage to these particular cells. Perhaps in the future, patients could receive an injection of a protective substance before undergoing radiotherapy.
It’s also possible, Oest theorizes, that patients could undergo something like a stem cell transplant after their therapy. Healthy cells could come from a donor, or from elsewhere in the patient’s body. She and Damron have learned that when radiation is applied to one leg, cells from the opposite leg remain undamaged. “In theory, if it worked, you could actually take cells from the healthy side of the patient and put them into the unhealthy side,” she says.
Oest and Damron are among dozens of researchers who have received grants from the Carol M. Baldwin Breast Cancer Research Fund of CNYsince 2002.
Megan Oest, PhD: Radiotherapy-associated bone damage[ 0.01 MB ]Play Now | Download
Estrogen is crucial to human life for men and women, but once a woman enters menopause, excess estrogen can lead to breast cancer. Up to 80 percent of the breast cancers detected in women after menopause are triggered and proliferated by estrogen, explains Debashis Ghosh, PhD.
Ghosh, a professor of pharmacology, collaborates with Juntao Luo, PhD, assistant professor of pharmacology, about ways to deliver new inhibitors of aromatase, the molecule that makes estrogen, to the tumor sites in animal breast cancer models. Having elucidated the molecular mechanism of how aromatase works, the Ghosh group has designed novel aromatase inhibitors, which are being tested in his lab.
“Some of our compounds have performed better, much better in breast cancer cells than the current drug, which is known as Aromasin or exemestane,” says Ghosh. The next step would be testing the compounds in laboratory animals.
Ghosh is one of dozens of Upstate researchers who have received grants from the Carol M. Baldwin Breast Cancer Research Fund of CNY since 2002.
Debashis Ghosh, MSc, PhD: The promise of aromatase inhibitors in treatment of breast cancer[ 0.01 MB ]Play Now | Download
Oncologist Srinivas Vourganti, MD tells what you need to know about bladder cancer, the 4th leading cancer diagnosed in men – how it’s diagnosed, how it’s treated and what preventives and screenings are recommended. Vourganti is assistant professor of Urology at Upstate Medical University.
Dermatologist Ramsay Farah, MD, talks about the importance of sun protection, and the limited sunscreen options available in the U.S. He discusses recent efforts to speed up U.S. Food and Drug Administration (FDA) approval of several new products that contain more effective ingredients. Farah is an associate professor of Medicine and Pathology, and chief of Dermatology at Upstate Medical University. Watch the video: How much damage does one sunburn do?
Ramsay Farah, MD: Sun protection and efforts to speed up the FDA approval process[ 0.01 MB ]Play Now | Download
Oral surgeon Terrence Thines, DDS, explains the risk factors, symptoms and treatment options for oral cancer, which includes cancers of the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx (throat). Thines is professor and chief of service, division of dentistry at Upstate Medical University.
Terrence Thines, DDS: Oral Cancer: Are You at Risk?[ 0.01 MB ]Play Now | Download
Ajay Jain, MD, associate director of hepatobiliary and pancreatic surgery at Upstate, explains the reasons for the rise in chronic hepatitis and helps us understand the connection between hepatitis B, the hepatitis C virus (HCV) and liver cancer.
Radiation oncologist Jeffrey Bogart, MD explains the full range of radiotherapy available at the new Upstate Cancer Center, including three new systems – Vero, TrueBeam, and TomoTherapy – that will provide even more precision and accuracy. The goal of radiation therapy is to get a high enough dose of radiation to the tumor while sparing the surrounding healthy tissue from damage. Bogart is professor and chair of Radiation Oncology and professor of Urology at Upstate Medical University.
Jeffrey Bogart, MD: Advanced radiotherapy coming to the new Upstate Cancer Center[ 0.01 MB ]Play Now | Download
Sharon Bauer, RN, nurse manager in the pediatric hematology/oncology department at Upstate Golisano Children’s Hospital, talks about what the new Upstate Cancer Center will mean for children in our community who are fighting cancer and blood disorders. Read the blog: Peds to Parents – Notes from Upstate Professionals to Parents and Caregivers.
Sharon Bauer, RN: New cancer center from the pediatric perspective[ 0.01 MB ]Play Now | Download
Leslie Kohman, MD, medical director of the new Upstate Cancer Center, is joined by administrator Dick Kilburg, MBA, to share exciting details about the center, which is set to open this summer. Kilburg will talk about what it took to bring this building to fruition – the biggest challenges, the unique building features, where we are today, and how much money was raised for construction. Kohman will describe the new services and technologies that will be available, how the building will facilitate multidisciplinary care, and what it will mean for patients who have cancer and their loved ones. The Upstate Cancer Center will be the only facility in the region to offer outpatient care and treatment for cancer and blood disorders in all ages – child through adult.
Leslie Kohman, MD and Dick Kilburg, MBA: Welcome to the new Upstate Cancer Center[ 0.01 MB ]Play Now | Download